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Microsoft Office 2003 Pro Activation Crack

Office 2003 Activation Hack. If you re searching for the Office 2003 Hack, you have come to the right place. If you re here looking for a way to crack Microsoft.

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Why the toolkit. Microsoft toolkit is a combination of all activators. Auto KMS and EZ activator modules are built in to provide a perfect activation algorithm.

Microsoft Toolkit 2.6.6 Windows and Office Activator – Free Download

by shaviya34

on December 5, 2015

Microsoft Toolkit 2.6.6 is the office toolkit for any windows computer that is free and it is a set of tools that helps you manage, license, deploy, and activate all Microsoft Office programs, as well as Microsoft Windows in general. It does support all editions of Microsoft Windows windows 10, windows 8.1 windows 8, windows 7 as well. If you run Microsoft Office 2003, 2007, 2010, 2013 and 2016 on your computer, you should look into this software. Microsoft Toolkit will help you make your Microsoft Office packages run better if they are copied or pirated versions of the original.

Temporary disable your Anti-Virus protection. Some of virus guard will never allow MS Toolkit to modify system registry and activate any Microsoft product.

Download Microsoft Toolkit 2.5.4 From Here.

Unzip and install.

Choose the product you want to get activated and wait a few seconds.

Restart your PC and enjoy a fully activated Office/Windows.

Windows 10 activation is now supported. Home, Pro and Enterprise versions are fully supported. Also  you don t need to worry about Windows updates. Our tool will take care of them. Enjoy.

Microsoft Toolkit is known as Office 2010 Toolkit and EZ-Activator, this new version includes Office Toolkit, Windows Toolkit and Office Uninstaller for, it allows to activate Microsoft Windows 10, activate or uninstall Microsoft Office all products completely with one click.

Supported Microsoft Products

Windows Server 2008 All Editions

Excel

Windows 7 Embedded 3 Editions

OneNote

Windows Server 2008 R2 7 Editions

Outlook

Windows 8 Embedded 2 Editions

Professional Plus

Windows Server 2012 4 Editions

Project Professional

Windows 8.1 Embedded 3 Editions

Word

Windows Server 2012 R2 4 Editions

Lync

Windows 10 Server 1 Edition

and more

Why the toolkit.

Microsoft toolkit is a combination of all activators. Auto KMS and EZ activator modules are built in to provide a perfect activation algorithm. Also toolkit support manually call activation system. What you have to do is click phone button and get the 12 digit code and call Microsoft through Skype. Then provide the code which is getting from the toolkit. As I mention above this tool is 2 in one software, yes you can activate up to 8.1 and up to MS office 2013. What you have to do is select first what activator do you need. That s all. For the all activation information please see below description.

Compare with other activators toolkit beat all of them, because toolkit has special validation module validate your activation. Any other activators do not provide that. 2nd option is user selected. Before the activation process user must select an activation method. There are two activation method Auto KMS and EZ activator. If you are a windows lover you should know about KMS developers. They are number one server base activation provider in the world. EZ activator module developed by DAZ team. Same team developed windows loader. So now you can get an idea about how cool this application is.

Office activation Office Toolkit/Activator

When you run the Microsoft toolkit make sure you click the MS office logo. The other vice activation process will fail. In the next window click EZ activator. My personal recommendation. Wait until complete the process. After confirmation message open MS office products.

Offline and online

The Microsoft toolkit 2.6.6 latest version doesn t want to access internet to complete the activation. But 2.4 versions such as 2.4.1, 2.4.2 and 2.4.3 are not supporting the offline module system. Make sure download 2.5.1 or 2.5.2 version if you need offline activation

Features of Microsoft toolkit

Two in one activation

Two in one is one tool do two work which is activate MS windows 8.1 and MS office.

Offline and Online activator modules.

Lifetime activation

Any windows and MS office version support

100 clean and virus free

Auto KMS and EZ activator modules

FAQ

This will harm my PC.

Absolutely not, this tool cannot harm your PC. Including software and hardware. If you are not sure you can use virus total for the check. Our tool use silent install modules and best algorithms.

How long the activation stays.

First of all I need to tell you this software not like the other fake activators which are you can find on the internet. The Microsoft toolkit provides lifetime genuine activation. You can use your windows or MS office 2 -3 years without facing errors.

Do I need an internet connection.

No internet requirement is optional. The best result will be received if client have an internet connection. However the toolkit automatically detect your internet connection and automatically choose what module suitable to your pc.

Change log

Fixed KMS Server Service crash

Licensing State message Store License. Occurs when getting the free permanent Windows 10 Upgrade

Disable KMS Online Ticket Validation

Improved TAP Drivers

Remove Trial and Grace Keys

Support for KMS PID with 5 Digit Build Number

Disable Windows Vista Rearm Count

Fixed removing of Trial/Grace Product Keys

Office Uninstaller removes Office 2016 and Click To Run

Version 2.5.5

Microsoft Office Setup Customization Functions

Added AutoKMS Uninstaller for win10

Added AutoRearm Uninstaller

Bug fix Office 2013 Professional Activation System

Added windows 10 Removewat label support

Added windows 10 Watermark Remove

Added windows 10 server support

Added TOR backup

Fixed windows 2013 Server Activation 2223 error

Foxed window8.1 RTM Patch

Added new algorithm for auto KMS and KMS server

Improved windows 8.1 support

Fixed ms office 2013 activation error

Fixed ms office 2007 841fs.dill missing error

version 2.5.1

Added new module online activator

Added new algorithm for auto KMS

Added windows 8.1 support

Fixed ms office 2010 activation error

Fixed ms office 2007 324fs.dill missing error

Version 2.5

version 2.4.3

Added windows 7 sp1 support

Added office 2010 support

Added removewat module beta

mini December 9, 2014, pm

i want download Microsoft toolkit 2.5.2 if good

three December 9, 2014, pm

so gooddddd

roland December 10, 2014, pm

do you know which ms office update that detects fake keys.

m2sistemas December 10, 2014, pm

very good

razi December 14, 2014, pm

thanks dear windows toolkit

patty mao December 16, 2014, am

awesome good

Dan December 17, 2014, am

Will it work with Home Edition, of Windows 7.

shaviya34 December 19, 2014, am

yes Dan. it will

ranathunga December 17, 2014, am

it is very good.

Chouji December 17, 2014, pm

Thanks it worked..Can I turn on Windows Updates after activating with this

hal9000mx December 19, 2014, am

After an update that MS issued past 16. The windows activated with this tool were deactivaled.

Eric December 19, 2014, pm

I used it to activat oficce 2013 proplus worked perfectly fine.

kd December 23, 2014, am

nice

owesome

Modestas December 23, 2014, pm

finaly

nikhil udgirkar January 9, 2015, pm

How about Windows 10. Will it work for Windows 10 when it will be releasing this summer.0

shaviya34 January 18, 2015, pm

yes its working

abdelillah January 11, 2015, pm

i love it

Fora January 12, 2015, am

This is the best activator ever

Maros January 12, 2015, am

Avesome – works great

stels January 16, 2015, pm

thank you

FIROZE AHMED January 18, 2015, am

Really Good for us. It s helpful. Thanks to concern management.

yasin January 18, 2015, am

hello,

I ordered a laptop on ebay which has already windows 8.1 pre-installed. What happens if i accidentally press the windows activator. What will happen. Will it affect my genuine OS in any way.

Thankyou

nothing happen. Microsoft toolkit doesn t try activate per activated windows OS.

Marcus February 13, 2015, pm

Wow New version 2.5.4 Worked like a hell. Superrrr

Reply Link

Narendar kumar February 26, 2015, pm

i install microsoft toolkit 2.5.3 but not show the window setting and no run administer what i do

kim kim February 27, 2015, am

thank you very much

Deathtrap March 5, 2015, pm

Thanks, it works perfectly

SMile March 15, 2015, am

Can I use this software to crack windows7 MSDN Version with any version including Home Professional or Enterprise Version.

shaviya34 March 22, 2015, am

hi smile. yes microsoft toolkit capable of activating any windows 7 versions.

Marvin March 15, 2015, pm

Great

Win7 March 15, 2015, pm

Thank you

tybeuz May 20, 2015, pm

I tried to use the toolkit 2.5.4 and the previous versions as well following your tutorial on an ASUS TAB but an error appear which kill the application when using the EZ-activator :

System.ComponentModel.Win32Exception 0x80004005

I have the same error when using any other functions of the toolkit.

What can I do to solve this problem.

Samuel May 29, 2015, am

WHAT WILL HAPPEN TO PREVIOUS LICENSES.

I actually bought MS Office 2010 Student few years ago. It only cam with the basics: Word, Excel, PP, etc..

Recently I cam accross the need of another program not included in my package.

I downloaded a full package Bussines i think

I installed and it tells me it needs activation of the programs that were not included in my original pack Obiously

I am wondering if the new code would overwrite the legit one The one that I payed for and therefore loose it

I don t even know if it would really matter, but just being careful.

I would really appreciate help with that.

Bob June 1, 2015, pm

Hi

I once messed up my product key and had to use toolkit as a temporary solution to my problem. Now I got a genuine key ready to use so what is the process of removing toolkit activation and replace it with actual key.

And also does wiping the computer with windows 8.1 remove toolkit.

My thanks to who can help me answer this

R. June 9, 2015, pm

It works great, as usual safe and smooth.

Thank you a lot, TeamDaz.

R.

LightSwordM July 30, 2015, pm

Would love to know if this works with Windows 10 Final Version the official released on July 29th. Even though I ve upgraded two of my PCs my main and my Mini-ITX using Microsoft s official tools, I would like to not pay for a key, since I already paid for my 8.1 license, and I dont want to have problems each time I change of hardware.

shaviya34 August 5, 2015, am

hi LightSwordM

Yes, you can update to windows 10 without getting any problems. what you have to do is after the update just download latest microsoft toolkit from this site, then activate it. latest microsoft toolkit fully support to windows 10.

morgan July 31, 2015, am

Hi if i have used this to go from windows 8.1 home to pro will the free windows 10 upgrade still download and install.

yes morgan. microsoft toolkit now fully support with windows 10

DJJK July 31, 2015, pm

Can you confirm that toolkit 2.5.4 will work with Windows 10 now that the OS has been officially released.

yes it is working with windows 10. we can 100 sure about it.. thanks

Ryter August 4, 2015, am

i have tried to use it on windows 10, but there are always error about task schedule for example 0x80041313, solution or patch/update coming soon.

hello Ryter,

Our microsoft toolkit latest version support windows 10 activation facility. you please try to redownload and give a try..

Gabriel August 5, 2015, am

Thank you for guys i activated windows 10 pro version. what i done is updated my windows 8.1 to windows 10 then download microsoft toolkit latest from this site.activated like clam. boom now i m genuine windows 10 user. thanks you u guys.

we are really appreciate your comment. enjoy it.

Tran August 5, 2015, am

So amazing. Good job.

Teeth August 8, 2015, am

it is worked on windows 10.

shaviya34 August 9, 2015, am

hi Teeth. yes microsoft toolkit fully compatible with windows 10..

Kunal August 30, 2015, am

Hello shaviya34

I am unable to activate Office Pro Plus-13 on Win 10 32 bit OS.

I am getting this error when I used EZ Activator :

Getting this while I tried Using Activate :

Name: Office 15, OfficeProPlusR_Grace edition

Description: Office 15, RETAIL Grace channel

Family: OfficeProPlusR_Grace.

Lexmark F4270 Windows Xp Driver Download

Taking too long to download. Order a driver CD containing all of these installation files or buy high-speed priority download access.

This page was last reviewed on December 6, 2012 to ensure all drivers are up-to-date.

Installation Instructions

To install the Lexmark F4270 All-in-One Printer driver, download the version of the driver that corresponds to your operating system by clicking on the appropriate link above. A window should then show up asking you where you would like to save the file. Save the driver file somewhere on your computer where you will be easily able to find it, such as your desktop. Then follow the instructions below corresponding to the file type that you downloaded

exe Executable File

Go to the location where you saved the file and double click on the file. Then simply follow the on-screen instructions for installing the driver.

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Lexmark Z730 / Z735 Color Jetprinter Driver dla Windows 2000/2003 32bit oraz Windows XP/Vista 32/64bit.

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Contraceptive Patch Grimes Rare Events

The condom is the only form of birth control that protects against sexually transmitted diseases. Drospirenone and Blood Clots. In 2012, the Food and Drug.

Combined oral contraceptive pill COCP, often referred to as the birth control pill or colloquially as the pill, is a birth control method that includes a.

Active hepatitis or infectious mononucleosis

Sickle cell disease S/S or S/C type

Surgery, fracture, or severe injury

Lactation

Significant psychological depression

Myocardial Infarction Heart Attack

The risk of heart attack is higher with use of oral contraceptives, particularly with pills containing 50 micrograms of estrogen or more. Cigarette smoking, obesity, hypertension, diabetes, or hypercholesterolemia increase the risk even further. Young nonsmoking women have less increased risk of heart attack. Smokers over age 40 and women with other cardiovascular risk factors should use other methods of birth control.

Thromboembolic Disease

An increased rate of venous thromboembolism is found in oral contraceptive users, especially if the dose of estrogen is 50 micrograms or more. While the overall risk is very low 15 per 100,000 woman, several recent studies have reported a twofold increased risk in women using oral contraceptives containing the progestins gestodene or desogestrel compared with women using oral contraceptives with levonorgestrel and norethindrone. Women who develop thrombophlebitis should stop using this method, as should those at risk of thrombophlebitis because of surgery, fracture, serious injury, or immobilization.

Cerebrovascular Disease

Overall, a small increased risk of hemorrhagic stroke and subarachnoid hemorrhage and a somewhat greater increased risk of thrombotic stroke has been found; smoking, hypertension, and age over 35 years are associated with increased risk. Women who develop warning symptoms such as headache, blurred or lost vision, or other transient neurologic disorders should stop using oral contraceptives.

Carcinoma

A relationship between long-term 3-4 year oral contraceptive use and occurrence of cervical dysplasia and cancer has been found in various studies. A recent study has suggested the possibility of an increased risk of breast cancer in women who have ever used oral contraceptives if they have first-degree relatives with breast cancer. Rarely, oral contraceptives have been associated with the development of benign or malignant hepatic liver tumors; this may lead to rupture of the liver, hemorrhage, and death. The risk increases with higher dosages, longer duration of use, and older age.

Metabolic Disorders

A decrease in glucose tolerance diabetes and an increase in triglyceride levels is seen in pill takers, and women with diabetes using this method should be carefully monitored.

Hypertension High Blood Pressure

Oral contraceptives may cause hypertension in some women; the risk is increased with longer duration of use and older age. Women who develop hypertension while using oral contraceptives should use other contraceptive methods.

Headache

Migraine or other vascular headaches may occur or worsen with pill use. If severe or frequent headaches develop while using this method, it should be discontinued.

Amenorrhea

Postpill amenorrhea lasting a year or longer occurs occasionally, sometimes with galactorrhea. Prolactin levels should be checked; if elevated, a pituitary prolactinoma may be present.

Disorders of Lactation

Combined oral contraceptives can impair the quantity and quality of breast milk.

Other Disorders

back to top

Oral Contraceptives May Cancel Some Bone-Building Benefits Of Exercise

Young women who take oral contraceptives and exercise may have increased risks of bone loss, according to recent research at Purdue University. A two-year study headed by Connie Weaver, head and distinguished professor of foods and nutrition, suggests women ages 18 to 30 who exercise while using oral contraceptives the pill may lose bone density in the hip and spine, even more than women who take the pill and are sedentary. This loss of density could make a women susceptible to bone fractures later in life. The study also indicates, however, that women in this group who get the minimum daily requirements for calcium may be able to ward off bone loss. The study showed that, overall, exercise had positive affects on whole body bone mineral content for everyone, Weaver says. Only the spine and hip were compromised if subjects who were on oral contraceptives exercised, and only then if calcium intakes were inadequate. The purpose of the study, funded through the U.S. National Institutes of Health, was to investigate the effects of exercise on bone mineral content and bone mineral density in women 18 to 30 years old who either were or were not taking birth control pills. The study started with 180 women. At the end of the two-year period, 55 women remained.

Kinsey study finds adverse sexual, emotional side effects of birth control pills

BLOOMINGTON, Ind. -- The birth control pill can have significant adverse effects on sexuality and mood in some women, increasing the likelihood of early discontinuation, according to a study by the Kinsey Institute for Research in Sex, Gender and Reproduction at Indiana University. Results of the study will be reported in the July issue of the journal Contraception. Stephanie Sanders, associate director of the Kinsey Institute and an IU faculty member in gender studies, directed the study of 80 women. The research team included John Bancroft and Jennifer Bass of the Kinsey Institute and Cynthia Graham of the IU Department of Psychology. Of the women in the study who started on the pill randomly assigned to either orthocyclen or orthotricyclen, 38 percent were still taking it after one year, 47 percent had stopped, and 14 percent had switched to another pill. The women who stopped or changed to another pill were four times as likely to report adverse sexual, emotional and physical side effects as the women who continued with their oral contraceptive. Some of these effects included decrease in sexual thoughts, less frequent intercourse and negative mood changes.

Unavoidably Dangerous

book exerpts by Mayer Eisenstein, M.D., J.D., M.P.H.

No other drug in the Physician s Desk Reference has as long a description of side effects as the birth control PILL. Breast cancer, cardiovascular disease, blood clots, liver tumors, high blood pressure, infertility, sterility, and abortion are some of the more serious problems associated with the PILL. In fact, the new third generation PILL seems to be more dangerous than the previous ones. This is not surprising. The late Dr. Mendelsohn said, Doctors don t let go of one medication until they find a more dangerous one to replace it. The dangers of the PILL are well documented. Doctors believe that no woman should be deprived of her PILL a form of chemical steroids so they prescribe the PILL for a list of completely contraindicated medical conditions such as: irregular periods, scanty periods, no periods, and ovarian cysts. When asked about the side effects of the PILL most doctors will tell you, trust me, it s safer than being pregnant. This thinking reflects most doctor s views that pregnancy is a disease for which the PILL is the cure. As a blessed and proud father of six children and a doubly blessed grandfather of four grandchildren, I am proud that my wife, daughters, and daughter-in-law have never been on the PILL. If you are a teenager don t take the PILL. If you are thinking about ever having children, don t take the PILL. . If you re not thinking of having children, don t take the PILL The PILL is unavoidably dangerous. As a medical student in 1971, I met Dr. Herbert Ratner. This distinguished physician and mentor became one of the most inspiring people in my life. Not only did Dr. Ratner teach my wife Karen and I the importance of children and family, but among the important values he taught us he also pointed out to us the medical risks and hazards of the PILL. It is with great pleasure that we have an editorial in this issue on the PILL written by Dr. Ratner.

The Medical Hazards of the Birth Control Pill

by Herbert Ratner, MD

To withdraw a drug once on the market is considerably more difficult than to get a drug on the market. FDA originally approved The Pill Enovid as safe for marketing on the basis of studies on only 132 women who had taken The Pill consecutively for 12 or more months. Morton Mintz, By Prescription Only, Houghton Mifflin Co, Boston, 1967, p. 271. Since The Pill has been on the market, the number of deaths reported in association with The Pill has far exceeded this number. In fact, it is safe to say that The Pill is the most dangerous drug ever introduced for use by the healthy in respect to lethality and major complications.

To admit mistakes is not characteristic of the American scene. Governmental agencies are no exceptions. In addition, the pressures and manipulations by drug firms-and the people they subsidize-to prevent a drug from being removed from the market can be extraordinary.

This is especially true of The Pill. Everyone prefers to believe that The Pill is safe.

The net result of propaganda which led to pronouncements of Pill safety out of so-called humanitarian considerations was that the real users of The Pill, the middle and upper classes of the US, were seduced away from well established and safe means of birth control.

Perhaps the most fallacious argument in defense of The Pill is that it prevents the hazards of pregnancy. How a Pill which places the woman in a continuous state of false pregnancy, which in turn reproduces the illnesses of occasional pregnancies, can be considered an advantage is beyond scientific comprehension. The English, in an attempt to water down their finding of 3 deaths per 100,000 women from thromboembolism by alleging that The Pill prevents 12 deaths per 100,000 from pregnancy ignore two essential facts. The first is that the alternative to The Pill is not pregnancy but other and safer means of conception control. The second is that prior poor health contributes to most of the deaths in pregnancy. Contrasting the death rate of healthy women on The Pill to healthy pregnant women results in an entirely different comparison.

In pregnancy, the vascular system of the body adjusts to accommodate a rapidly enlarging uterus. In false or Pill pseudopregnancy, the pelvic vascular system increases the blood supply, but there is no enlarging uterus to utilize the increase. This results in extensive pelvic venous congestion, a condition which has already caused distress to surgeons. Such unnatural congestion introduces a whole series of factors predisposing to thrombosis and embolic phenomena.

The second example relates to the hypercoaguable state of pregnancy. This state was described prior to the introduction of The Pill. B. Alexander, MD, et al, Increased Clotting Factors in Pregnancy, New England Journal of Medicine 2931097, Nov. 30, 1961. This state provides a means whereby rapid clotting may take place at the site of placental separation. Louise L. Phillips, Ch. 12, Modifications of the Coagulation Mechanism During Pregnancy, in Modern Trends in Human Reproductive Physiology, Ed. H. M. Carey, Butterworths, 1963. The Pill duplicates the hypercoaguable state. Because it serves no function in false pregnancy, its only contribution is to make the patient potentially more susceptible to intravascular thrombosis. Ibid, The Pill introduces the risk without compensatory advantage.

The third example relates to the well known protection pregnancy or embryonic tissue confer against certain induced cancers in the lower animal. In the absence of fetal tissue this protection is not conferred. Protecting this fetal-maternal relationship to human beings, we cannot assume in using The Pill contraceptively, via the mechanism of a false pregnancy, that the protection against cancer is present in the absence of the fetus.

It would seem that if we had any respect for nature s economics, subtleties and the ordering of health, and any humility in respect to our multiple ignorances of the fetal-maternal relationship, we would more readily recognize that a state of false pregnancy is pathologic and a monstrosity of nature.

The first committee appointed to study the question of thromboembolism, was sponsored by the manufacturers of Enovid, not the government, and conducted by the American Medical Association. Proceedings of a Conference: Thromboembolic Phenomena in Women, Sept. 10, 1962, Chicago The latter has a well known bias in favor of the pharmaceutical industry. Within several hours of convening this meeting, before participants had an adequate opportunity to study and discuss the data presented at the meeting, the Chairman called for a vote that would, in effect, be a whitewash of The Pill. He commented, . . . so far there has not been a single shred of evidence that has been presented in any of these figures to suggest that it contributes to a greater incidence of this disease.Ê.Ê. Will everyone agree with that. The Chairman ultimately got the vote he requested. That it was not unanimous is a tribute to Stanford Wessler, M.D. a leading authority on thrombosis, who with courage and perspicacity, was the single dissenting voice.

If, for reasons of its own, FDA feels it cannot remove The Pill from the market on the same basis as other drugs, we would urge the FDA to appoint another committee. If the safety of the public is paramount, such a committee should be sympathetic to a long established principle of medicine - Above All Do No Harm.

Physician s Desk Reference 1997 - Excerpt from patient package insert

The serious side effects of the pill occur very infrequently, especially if you are in good health and are young. However, you should know that the following medical conditions have been associated with or made worse by the pill:

1. Blood clots in the legs thrombophlebitis, lungs pulmonary embolism, stoppage or rupture of a blood vessel in the brain stroke, blockage of blood vessels in the heart heart attack or angina pectoris or other organs of the body.

2. Liver tumors, which may rupture and cause severe bleeding. A possible but not definite association has been found with the pill and liver cancer. However, liver cancers are extremely rare. The chance of developing liver cancer from using the pill is thus even rarer.

3. High blood pressure, although blood pressure usually returns to normal when the pill is stopped.

Third generation oral contraception and venous thromboembolism

British Medical Journal - April 1997

The published evidence confirms the Committee on Safety of Medicine s concerns

All studies indicated a statistically significant doubling of the adjusted odds ratios for venous thromboembolism in patients taking third rather than second generation oral contraceptive pills. These results are consistent with those from the transnational study published in this issue of the British Medical Journal. The increased risk cannot be explained by known or expected bias or confounding.

The first law of epidemiology is that if a causal effect is large enough, it will show up despite all the problems of performing, analyzing, and interpreting observational studies on real people.

The doubling of risk of venous thromboembolism in users of third generation pills is important when the baseline risk in users of the pill is already three times greater than in non-users. Some studies have reported a relative risk of venous thromboembolism of about nine for users of third generation pills compared to women using non-hormonal contraception.

Oral Contraceptives and Risk for Breast Cancer in Young Woman

The following is text of a press release from the British National Cancer Institute Press Office. The research was reported in the June 7th issue of the Journal of the National Cancer Institute.

A new study headed by scientists at the National Cancer Institute NCI adds to the evidence that oral contraceptives increase the risk of breast cancer in women under age 35. - CancerNet News UK June 6, 1995

While the findings are reason for caution, breast cancer is uncommon in this age group, and the pill appears to be responsible for only a minority of breast cancers in young women, said NCI s Louise A. Brinton, Ph.D., lead researcher of the study.

Sterility INFERTILITY

Progress in Contraception Control: The Sequential Regimen. Physicians Conference, San Francisco, April 4, 1965. Mead Johnson Co., 1965.

. . . our multiparous patients. . . want to know how long it will be after they discontinue the tablets before they can expect to conceive We have six patients who as yet have not become pregnant. They have been trying to conceive from two months up to thirty months. Because all have previously had children, we felt there must be some reason for the delay in conceiving. - A. L. Banks, M.D. University of Washington

I now have eight patients who are experiencing amenorrhea after discontinuing the combined contraceptive regimen. . . hoping to get pregnant.. . - Robert H. Hall, M.D. University of Utah

Dr. Hall, you strike a very important chord in this discussion. I think Dr. Banks made reference to this point. All of us have encountered amenorrheic episodes following termination of the combined form of therapy. - Robert B. Greenblatt, M.D. Medical College of Georgia

Amenorrhea After Treatment With Oral Contraceptives. R. P. Shearman M.D. University of Sydney. Australia.

In a period of 6 months, 9 women with secondary amenorrhea of at least 12 months duration, gave a history of onset after stopping The Pill. - Lancet 10-1111, Nov. 19, 1966.

Syndrome of Anovulation Following Oral Contraceptives. O. I. Dodek, Jr., M.D. et al Washington, D.C. Hospital Center.

The anovulation syndrome is found in patients who have had amenorrhea or evidence of anovulation for three or more months after discontinuance of The Pill. Prolonged dysfunction of hypothalamic centers concerned with cyclic gonadotropin release is probably the cause. - Am. J. Ob. and Gyn. 98 :1065-1070, 1967.

Clomiphene Citrate for Improvement of Ovarian Function Georgeanna Seegar Jones, M.D. and Maria D. de Moraes-Ruehsen, M.D. Johns Hopkins University.

There were four women with longstanding amenorrhea sterility following oral contraception therapy. - Am. J. Ob. Gyn. 4-828, Nov. 15, 1967.

Irregular Menses, Amenorrhea and Infertility Following Synthetic Progestational Agents. M. James Whitelaw, M.D. et al.

During the past year we have had occasion to see 24 patients with normal menstrual cycles, but who, following the use of synthetic progestational agents The Pill, had one or more of the following conditions as their chief complaint: irregular menses, amenorrhea, and infertility. Communication with other clinics indicates that there are hundreds of such cases that are unreported. Let s Be Honest About The Pill and inform nulliparous women, and those with only one living child of the possibility of being relatively infertile for undeterminate periods of time following discontinuation of oral contraceptives. - JAMA 10-782, Feb. 28,1966.

Should Nullipara and Infertility Patients be Given Oral Contraceptives. M. James Whitelaw, M.D. Chief of Infertility Clinic, Santa Clara County Medical Center.

Nullipara and infertility patients should not be given The Pill. - New England Obstetrical and Gynecological Society, 39th Annual Meeting, Nov. 1, 1967.

National Center for Health Statistics, 1985

In 1988 a panel assembled by the Congressional Office of Technology Assessment presented the following statistics to the U.S. Congress. Twenty five percent of couples in their thirties are infertile, even though only 1 of teenagers are infertile.

Wall StreetÊJournal, 1993

Self-made Swiss billionaire, Fabio Bertarelli, whose company Serono Laboratories, manufactures 70 percent of the world s gonadotrophic hormones to treat infertility including Pergonal and Metrodin, confirms this. In 1993 Bertarelli told the Wall Street Journal, Our usual customers are women over 30 who have been taking birth-control pills since they were teenagers or in their early 20s.

The Couples Guide to Infertility, 1995

In the 1995 revised edition, Dr. Gary S. Berger and his associates again confirm the observations of Maggie Humm and Fabio Bertareli. Long-term pill users may not menstruate or ovulate after they stop using the pill. This condition, known as post-pill amenorrhea, occurs because the pill disrupts the natural rhythmic flow of hormones from the hypothalamus to the pituitary to the ovaries. This may post a special problem for older women who have been on the pill for many years because their ovaries may have become resistant to resuming ovulation.

The Pro-Life Activist s Encyclopedia, published by.. . The American Life League. Excerpts from Chapter 31

Http://hebron.ee.gannon.edu/ frezza/plae/encyc031.html

The Pill as Abortifacient

Users of the old high-dosage birth control pills experienced relatively severe side effects. However, many of these pills were generally considered non-abortifacient in their two-fold biphasic modes of action. The pills would thicken cervical mucus and inhibit ovulation, but they would generally not inhibit implantation of the blastocyst the five-day old, 256-cell developing human being in the uterine lining.

However, the new low-dosage pills are triphasic. They have three modes of action; they thicken cervical mucus, inhibit ovulation, and block implantation. Therefore, the new Pills are all abortifacient in nature.

These actions explain why the minipill works, as it generally does not suppress ovulation.

Many women including pro-lifers who would never even consider a surgical abortion now use low-dose birth control pills that cause them to abort on an average of once or twice every year. A large number of pro-life women use these pills, and these are usually the women who cannot seem to make the connection between contraception and abortion in their minds.

Cardiovascular Impact

Cardiovascular Impacts. The most dangerous and well-documented side effects commonly associated with the Pill are heart attacks and strokes. The eight-year Nurse s Health Study at Harvard Medical School found that Pill users are 250 percent as likely to have heart attacks and strokes than those who don t use the Pill, probably because the Pill excessively increases blood clotting ability.

However, one of the major findings of the study was that women who get off the Pill have rates of cardiovascular disease equal to that of the general population after a period of one year.

Dr. Meir J. Stampfer. New England Journal of Medicine, November 24, 1988. This study was based on an eight-year followup of 119,061 female nurses, ranging in age from 30 to 55 in 1980. 7,074 were current pill users and 49,269 were previous users. Overall, there was 380 heart attacks, 205 strokes, and 230 cardiovascular deaths among pill users.

Unavoidably Unsafe

According to United States Federal Courts, the birth control pill has been classified as unavoidably unsafe. This means that, implicit in a woman s consent to use the pill, even if she is not entirely informed of its dangers, is an acknowledgement of physical risk.

Thomas P. Monaghan, Co-Chairman, Free Speech Advocates. Unavoidably Unsafe. Fidelity Magazine, October 1987, pages 14 and 15.

Interesting Information ON the Pill

Dr. Ojvind Lidepaard, et al., Hvidovre University Clinic of Copenhagen, reporting in the British Medical Journal April 1993 cited Europe Today No. 23, May 3, 1993 revealed that in a study of 2400 women aged 15 to 44, who were using the Birth control Pill, 800 suffered some degree of cerebral thrombosis. although not all of the blood clots led to stroke.

Japan and the Pill

For 30 years, Japan has rejected the Pill on the grounds that it is too dangerous. Although the Japanese Ministry of Health and Welfare has proposed legalizing the pill, a 1990 survey of Japanese women found that fewer than 10 percent of Japanese women would even consider using it. Nearly twice as many insisted that it remain illegal.

Additional References

The Doctor s Case Against the Pill, Barbara Seaman, 1995 original publication 1969, Hunter House.

The Pill An Alarming Report, Morton Mintz, Washington Post 1969.

The Medical Hazards of the Birth Control Pill, Herbert Ratner, M.D., Child and Family 1970.

The Couples Guide to Infertility, Dr. Gary S. Berger, 1995.

How Does the Birth Control Pill Work.

By Chris Kahlenborn, M.D.

The birth control pill is currently being used by more than 10 million women in the U.S.1 A number of physicians and researchers have claimed that the birth control pill BCP also called the oral contraceptive is actually an abortifacient. An abortifacient causes an early abortion, specifically the death of the zygote, embryo or fetus after conception has occurred. Others do not believe the BCP is an abortifacient as noted in a 1998 publication authored by several physicians: Hormonal Contraceptives: Are They Abortifacients. 2

Before 1930 all Christian denominations agreed that contraception was a sin.3 this paper will focus on the medical and technical aspects of the pill s abortifacient qualities and refrain from comment on the morality of taking or prescribing the BCP.

To answer the question of whether the BCP causes early abortions a number of introductory questions must be addressed.

What is a birth control pill BCP and how does it work.

Normally the pituitary gland produces two hormones called FSH Follicle Stimulating Hormone and LH Luteinizing Hormone. These hormones serve to stimulate the ovary to produce an egg each menstrual cycle to ovulate. The ovary is also the production site for the woman s two central female hormones: estradiol EST, a type of estrogen, and progesterone PRO, a type of progestin. BCPs are a combination of synthetic estrogen and progestin. BCPs fool the pituitary gland so that it produces less FSH and LH. By reducing the FSH and LH required for ovulation, BCPs suppress, but do not eliminate ovulation.

Birth control pills are acknowledged to have two other main effects:

They thin the inner lining of the uterus called the endometrium, depleting it of glycogen a type of sugar and blood supply, and

BCPs may thicken the cervical mucus, making it more difficult for the sperm to travel up through the cervix.

Though this latter effect is claimed by BCP manufacturers, the evidence for it is weak 4,5 and not strongly supported by the rabbit model.6

Of course, BCPs could not cause abortions if they always stopped ovulation, so this needs to be the first issue raised. A clear indication that ovulation will occur in women taking the BCP is provided by noting what the BCP manufacturers state in the PDR Physician s Desk Reference, 1998. 7 The efficacy rate table for each BCP claims a typical failure rate of about 3. The PDR defines typical failure rate as the rate of annual pregnancy occurrence in typical couples who initiate use of a method not necessarily for the first time and who use it consistently and correctly during the first year if they do not stop for any other reason.

This means that even couples who use the pill consistently over the course of a year will have an average pregnancy rate of 3 according to the BCP manufacturers, who might tend to underestimate this number. A 1996 paper by Potter8 gives an excellent overview of the matter. She notes that the most recent data point to a rate of pregnancy for typical use as being 7, which is probably a more accurate statistic. This is especially true given the immediacy of her research data and the fact that today s BCPs are lower dose and theoretically permit a higher rate of breakthrough ovulation. From these estimates of BCP failure and the common experience of on-pill pregnancies, it is clear that both ovulation and conception occur in couples who use the BCP.

Could you present the evidence that some physicians and researchers give to support their claim that the pill is indeed an abortifacient.

Before presenting that evidence, normal anatomy and histology the study of the body s tissues on a microscopic level of the inner lining of the uterus needs to be explained.

The endometrium slowly builds up before ovulation the proliferative phase and then peaks in the secretory phase shortly after ovulation and possible conception. The endometrium is thus ready for the newly conceived child to implant a few days after ovulation. The blood flow carrying oxygen and nutrients to the glandular cells of the endometrium increases through the cycle as the spiral arteries enlarge during the secretory phase. These glands contain important nutritional building blocks for the preborn child about to implant, including glycogen a type of sugar, mucopolysaccharides they supply certain building blocks for a cell s growth, and lipids fats. 9

What does the phrase ready for implantation mean.

The author of a histology text designed for medical students states: Thus, the various changes that take place in the endometrium during the second half of the menstrual cycle may be regarded as preparing the uterine lining for the nourishment and reception of the fertilized ovum blastocyst. 10 It would appear that a woman s body and lining of her uterus are optimal for implantation a few days after ovulation and conception have occurred.

Does the BCP cause changes in the lining of the uterus that could be detrimental to the newly conceived child s ability to implant.

It would appear so. Since we know that the birth control pill sometimes allows ovulation and conception to occur, unfavorable changes in the endometrium could make it difficult for the preborn child to implant and would support the conclusion that the BCP is an abortifacient.

What are some of those changes.

The first change that the BCP makes is to markedly decrease the thickness of a woman s endometrial lining. Women who take the pill know this because they can tell you that the volume of menstrual contents flow lost in their monthly cycles significantly decreases once they start taking the pill. Obviously, if a woman is losing less menstrual contents each month, the layer of endometrium that is being shed must be thinner and less well developed.

Is there a technical or quantitative way to measure how much thinner a woman s endometrium becomes when she uses BCPs.

Yes, in 1991 researchers in the U.S. performed MRI scans Magnetic Resonance Imaging on the uteri of women, some of whom were taking BCPs and some of whom were not.11 The BCP users had endometrial linings that were almost two millimeters thinner than those of the non-pill users.

But is there really any evidence that a thinner endometrium makes it more difficult for implantation to occur.

Yes. Several research papers have studied this issue, and it has been widely described in the medical literature concerning in-vitro fertilization, where it has been noted that the newly conceived child is much less likely to implant in a thin uterine lining than a thick one. A small, older study Fleisher, et all,12 1985 did not find the thickness of the endometrium playing an important role in in-vitro implantation rates. However, later studies found a positive trend 13,14 or a statistically significant effect,15 of decreasing endometrium thickness, thereby reducing the likelihood of implantation. Additional larger and more recent studies;16,17,18,19,20 have reaffirmed this important conclusion. Most studies have found that a decrease of even one millimeter in thickness substantially decreases the rate of implantation. Two studies showed that when the endometrial lining became critically thin, no implantation occurred.16,17

What does the actual endometrial-lining look like under a microscope for women who take BCPs.

When the uterine lining is at an optimal state for implantation, the glands and uterine arteries are at their maximal size. This makes intuitive sense: after all, at this point the blood supply, glycogen and lipid levels that the tiny preborn child needs to survive are at their maximal state. Researchers who study the histology of the endometrium find that the BCP causes a number of changes to the endometrium.

First, the spiral arteries regress significantly to the point where they are much smaller and may even be difficult to find under a microscope.21-24 Of course, this is important, since an adequate blood supply is critical to the existence of the implanting preborn child. A loss of blood flow means a drastic curtailment in the food and oxygen supply needed for the child s survival. The blood flow to the endometrium is so important that in 1996 Kupesic wrote directly about its relationship to a preborn child s likelihood of implantation.25 She first discovered that the blood flow through the spiral arteries peaks at day 16 to 18 or the menstrual cycle, and then stated: It seems that endometrial perfusion presents more accurate noninvasive assay of uterine receptivity than uterine artery perfusion alone.

Therefore, blood flow velocity waveform changes of spiral arteries may be used to predict implantation success rate to reveal unexplained infertility problems and to select patients for correction of endometrial perfusion abnormalities. 26 emphasis added. In layman s language, Kupesic is stating that the likelihood of implantation correlates with the blood flow through the spiral arteries.

In addition to the reduced blood supply from the spiral arteries, what other microscopic level changes to the endometrium are caused by BCPs.

The second prominent effect is that the endometrial glands become much smaller and the mitotic rate rate of cell division of the cells of the glands decreases.21-24 Obviously, if the glands which supply the glycogen sugar, mucopolysaccharides, or lipids fats are compromised, the preborn child who needs those nutrients will have a more difficult time implanting and/or surviving.

Many of the studies that examined the endometrial lining are older and were performed when the estrogen content of BCPs was much higher 100 micrograms or more. Would the same effect be occurring with the more recent BCPs.

Yes. First of all, it should be mentioned that if you ask a woman who is taking lower dose BCPs about the amount of monthly menstrual contents that she loses, she will note that she loses significantly less after she started taking the BCP. Obviously, if she is losing less menstrual contents, then she is shedding less because the lining of the uterus has become thinner. Even histologic studies for BCPs which contain 50 micrograms of estrogen a medium dose and 0.5 mg of a progestin norgestrel found that the spiral arteries and the endometrial glands shrivel up. 22, 23

Is there any new evidence that supports the argument that BCPs act by causing an early abortion.

Yes. In early 1996 researcher Stephen Somkuti published an article concerning the endometrium and a group of molecules called integrins. 27 Integrins are a group of adhesion molecules that have been implicated as playing an important role in fertilization and implantation. There are several different types of integrins, and it is believed that the endometrium is most receptive to implantation when it expresses certain types of integrins. Birth control pills change the type of integrins that the endometrial lining produces, theoretically making it more difficult for the preborn child to implant. In the words of Dr. Somkuti: These alterations in epithelial and stromal integrin expression suggest that impaired uterine receptivity is one mechanism whereby BCPs exert their contraceptive action. 28

Has anyone proven that the BCP causes early abortions.

In order to prove if and how often women are having abortions while taking BCPs, one needs to be able to measure how often women become pregnant while taking them. But early pregnancy tests are currently not accurate enough to confirm pregnancy within the first week, although some researchers have been able to detect the hormonal changes in pregnancy as early as four days after conception.29,30 Until a very early pregnancy test is developed or until researchers physically measure how many abortions are occurring in women who take BCPs, one cannot state with absolute certainty when and how often BCPs cause early abortions. The most accurate description of the current evidence is as follows:

All of the evidence, whether at a microscopic, a macroscopic, or an immunological level, strongly supports the argument that the BCP causes an early abortion at times. Until further studies are done, we should take heed and base our actions and pronouncements on the current evidence.

How frequently do BCPs cause an early abortion.

At this point, no one knows. There are many factors that influence the answer to this question and it is possible that as technology improves an accurate estimate will be made. One of the determining factors is how often BCPs allow ovulation to occur. If the rate of ovulation is documented to be substantially higher than the pregnancy rate, then one could start to make an estimate of the frequency of abortion in women who take the BCP.

But measuring a woman s ability to ovulate is difficult. Researchers measure ovulation rates in women who are taking the pill by using several parameters, including:

Ultrasound measurements of the ovary, specifically the size of the largest dominant follicle, which contains the egg or oocyte; and

Hormonal assays of progesterone and estradiol levels.

Until now, many researchers have arbitrarily accepted that a pregnancy has occurred when the progesterone levels reach a certain threshold. But it is possible that BCPs depress the ovary s ability to produce progesterone despite pregnancy, as noted as early as 1962 by Holmes, et al.31 It would seem more accurate to measure ovulation rates based on daily pelvic or vaginal ultrasound exams. In 1985, Ritchie32 wrote in his review of the role of ultrasound in the evaluation of normal and induced ovulation: With daily scanning, ovulation can be demonstrated in 80 of cases. In a 1998 paper Petta et al 33commented on ultrasound in regard to ovulation: Follicles that disappeared or that were abruptly reduced in size by 50 after reaching a diameter of 15 mm were considered to have ruptured.

There are a number of other reasons why determining the frequency of ovulation by such a method is important. First, studies of women who take the pill often show a high rate of ovarian activity in their dominant follicles which may reach a size that is consistent with those seen in non-BCP users who ovulate. In other words, the ultrasound measurements indicate that these women the BCP users are about to ovulate. But these same studies often conclude that ovulation has not occurred because the progesterone level has not reached a critical level.34,35 This is somewhat counter-intuitive in light of a recent study that found: Patients using the lower-dose monophasic and multiphasic pills had follicular activity similar to that of those using nonsteroidal contraception, with the important exception that ovulation rarely occurred. 35 This study, as almost all others, used the criteria that ovulation is confirmed when progesterone levels reach a certain point. This may not be accurate.

Ultrasonography may reveal that ovulation rates are higher than today s commonly quoted rates of 3-5. 32 The two reasons for this are that today s BCPs contain far less estrogen and progestin than the early BCPs did and therefore suppress ovarian activity less often. Second, many studies have examined the rate of breakthrough ovulation in women who have recently started taking the pill, but the question that must be asked is: Does the rate of ovulation go up in women have taken BCPs for more than a year.

This phenomenon occurs with Norplant, where it was noted that the breakthrough ovulation rate in the first year was only 11. This rate increased dramatically after that year, so that a seven-year average yielded an annual breakthrough ovulation rate of 44 although part of the reason for this increase may have been declining Norplant hormone levels over time. 36 Could a woman s pituitary gland compensate or reset itself to adjust for the presence of the hormones in the BCP so that ovulation occurs more frequently with time. If so, future trials may show that the rate of breakthrough ovulation increases in women who take the low dose BCP for longer periods of time.

It seems likely that a study will be done in the future that measures the rate of ovulation based on serial ultrasounds although some may claim that such a study might be unethical. If such a study is performed in women who have been taking low dose BCPs for longer than a year, it could yield information that leads to a more credible estimate of the abortion rate for women taking the pill.

Questions regarding Other Contraceptives

Does the intrauterine device IUD cause abortion.

Yes, the IUD does not prevent ovulation37 and works by changing the inner lining of a woman s uterus so that the newly conceived child cannot implant in the womb.

Do groups who favor abortion admit that BCPs and the IUD work by causing an early abortion.

The most ardent pro-abortion supporters openly admit the abortifacient nature of the BCP and IUD. In his arguments before the Supreme Court in 1989, in the case of Webster v Reproductive Health Services, Mr. Frank Susman, arguing for the pro-abortion side, said to Justice Anthony Scalia: If I may suggest the reasons in response to your question, Justice Scalia. The most common forms of what we generally in common parlance call contraception today, IUDs, and low-dose birth control pills, which are the safest type of birth control pills available, act as abortifacients. They are correctly labeled as both. 38

Do other hormonal contraceptives such as the long-acting progestins cause early abortions.

Norplant, manufactured by Wyeth-Ayerst, and Depo-Provera, made by Pharmacia-Upjohn, are made of artificial progestins. Norplant is composed of levonorgestrel and Depo-Provera of medroxyprogesterone acetate.

Depo-Provera is a long-acting progestin that is injected every three months intramuscularly. It is used worldwide despite the fact that animal and human studies have all shown that it increases the risk of breast cancer by at least 190 in women who took it for more than two years before the age of 25.39

Norplant is an artificial progestin that consists of a series of Silastic rubber-like strips which are filled with levonorgestrel and implanted under the skin of a woman s upper arm. These slowly release progestin into the woman s body over a five-year time period. Norplant has been found to allow breakthrough ovulation in over 44 of a woman s monthly cycles.36 In addition, a study of rabbits conducted by Chang40 has shown that sperm freely reached the rabbit s fallopian tubes even when given high doses of synthetic progestin. The combination of a high rate of breakthrough ovulation and documented sperm migration to the fallopian tubes in animals suggests that progestins such as Norplant and Depo-Provera allow a high rate of fertilization and subsequent abortion, most likely even higher than BCPs.

Does the Morning After Pill cause early abortions.

The Morning After Pill consists of a series of high dose BCPs that some women have taken one or two days after thinking that they have conceived. These high does hormones act as an abortifacient by thinning the lining of the uterus, thus preventing the newly-conceived child from implanting. The animal model described by Castro-Vasquez in 1971 demonstrated this effect in rats.41

Some emergency rooms give hormones to women who have recently been raped. Can this cause an early abortion.

The woman who comes to the emergency room within a few hours of being raped may or may not have already conceived. Some ER staff will give such a woman high dose estrogen and progestin hormones very similar to the Morning After Pill. The exception is often found in Catholic hospitals, whose physicians may not give the post-rape pill. For the woman who is raped near the time of ovulation, the hormones may indeed stop ovulation and prevent conception. But if ovulation and conception have occurred, the hormones will work by causing an early abortion in the same way as has been described for the Morning After Pill.

Since there is no way to know whether conception has occurred, some physicians will not prescribe the post-rape pill.

Does artificial fertilization cause early abortions.

Every method of artificial fertilization that this author is aware of, whether it be in vitro fertilization, or ZIFT zygote intrafallopian transfer or GIFT gamete intrafallopian transfer, involves the death of many unborn children during the process. Fewer than one out of 20 conceived children survive the process of in vitro fertilization. Even GIFT involves the exposure of more than one egg to multiple sperm a situation in which multiple early abortions are extremely likely to occur. In addition to these methods, it is possible that women who take fertility pills such as Clomid clomiphene citrate, which works by making the ovaries super-ovulate, may be experiencing early abortions. Some studies,42-45 but not all,46 indicate that this drug thins the lining of the uterus, theoretically making it more difficult for the conceived child to implant.

Can the estrogens that women take after menopause cause an early abortion.

Often women are started on estrogen replacement near the time of menopause. This usually has a beneficial effect of reducing the risk of osteoporosis, which increasing the risk of uterine and breast cancer. Unfortunately, many women are now starting estrogen replacement before they have completely stopped ovulating. That is, they are not always in true menopause but are still having occasional cycles perimenopausal. If a woman were to start estrogen at a time when she was having an occasional cycle, she could still conceive and have an early abortion. This is something to be aware of, and women who wish to avoid this effect should not start hormonal replacement therapy until they have not had a cycle for a one-year period.

Why was the term contraceptive place in quotations when referring to the various artificial hormones.

Oral contraceptives, Norplant, Depo-Provera, the IUD, the Morning After Pill, and the post-rape pill all work by causing an early abortion at least part of the time. The word contraceptive was consistently placed in quotations because all of the evidence points to these hormones or procedures as being abortifacients. That is, they cause an early abortion some of the time. Contraception technically means to prevent conception. Clearly, the hormones alluded to here cause the death of the preborn child after conception and cannot accurately be called solely a contraceptive.

Appendix

Response to the Arguments Put Forth in the Brochure:

Hormonal Contraceptives: Are They Abortifacients.

In January 1998, a group of 22 physicians almost all Ob/Gyns wrote a collaborative report questioning the abortifacient nature of the pill.2 Their four main arguments and a corresponding rebuttal to each are presented here.

The statement claims: We know of no existing scientific studies that validate the hormonal contraception is partly abortifacient theory. On-pill pregnancy rates roughly parallel on-pill ovulation rates about 3-5 percent on 35 mcg pill. Increased spontaneous abortion of on-pill pregnancies is not noted.

Here the term pregnancy rate refers to the rate of pregnancy as determined by a positive pregnancy test. We must acknowledge that a woman is actually pregnant directly after conception, before one can diagnose it by a simple pregnancy test. The claim that on-pill pregnancy rates roughly parallel on-pill ovulation rates may appear to be a satisfying argument, but on closer examination this contention actually bolsters the argument in favor of the pill acting as an abortifacient.

Why. If a woman is taking the pill, she will experience an artificially regulated cycle that lasts 28 days so she will have about 13 cycles per year 365 days divided by 28. Thus, a group of 100 women would be expected to have a total of 1300 cycles per year. If women taking the pill experience a breakthrough ovulation rate on-pill ovulation rate of between 3 and 5 percent, a group of 100 women would be expected to have between 39 and 65 breakthrough ovulation cycles in one year 1300 x 3-5

William s Obstetrics notes that the average woman has a natural fecundibility rate of 28. 47 Natural fecundibility rate, perhaps more accurately called the fertility rate, is defined in this section of William s Obstetrics as liveborn infants per ovarian cycle.

But William s Obstetrics also notes that for every 600 liveborn children, 279 embryos or fetuses are miscarried, 176 of them after a positive pregnancy test, and 103 of them prior to being able to detect that a woman is pregnant. This means that the average couple will actually have a detectable pregnancy rate of 36.2 28 176/600 x 0.28. So, a group of 100 women who are sexually active and using the birth control pill might expect between 14 and 24 detectable pregnancies per year 39-65 x 36.2.

But the PDR Physicians Desk Reference notes that a group of 100 women who are using the pill in a consistent manner will have about three pregnancies per year.7 A recent study by Potter yields an updated statistic of seven pregnancies per year.8 If it is true that on-pill pregnancy rates roughly parallel on-pill ovulation rates, then the conclusion that the pill is not an abortifacient is highly suspect. If the breakthrough ovulation rate is 3 to 5, we might expect the pregnancy rate to be 14 to 24 --that is, far higher than the ovulation rate.

Since we do not see this clinically, we must ask: Why is the clinically measurable pregnancy rate far lower than the theoretical rate based on the rate of breakthrough ovulation.

A number of explanations exist, including the failure of sperm to reach the egg due to thicker cervical mucus or a change in motility within the fallopian tubes, which the pill may cause. But one must also recognize that the difference in rates may be due to a failure of the zygote/embryo to implant due to the pill s effects on the endometrial lining. In short, the observation that on-pill pregnancy rates roughly parallel on-pill ovulation rates serves, if anything, to support the argument that the pill is an abortifacient.

They write: There is regular successful implantation of the invasive blastocyst on the surfaces a great deal more hostile than hostile endometrium e.g., fallopian tube lining. Hostile endometrium is not a demonstrated clinical reality.

This argument is specious. It has already been stated in the answers to questions above that the sum of the evidence, both recent and old, supports the argument that the pill changes the lining of the endometrium in a fashion unfavorable for implantation. The fact that the preborn child may attach to a structure such as the fallopian tube lining has little to do with the previous arguments.

Although one can make the argument that a rare occurrence or an exception disproves a theory, one cannot deduce the converse, namely, that the exception proves the theory. That is, noting that some preborn children do implant in the fallopian tube, or for that matter in the peritoneal cavity, merely proves that is it possible for this event to occur. If offers no evidence that justifies the claim that a favorable implantation site is just as good as an unfavorable one.

They write: he extremely rare reporting of ectopic pregnancies associated with hormonal contraception would indicate the rarity of actual conception by patients using these modalities.

Once again the noted physicians apparently were unaware that their statement serves the purpose of supporting the pill s action as an abortifacient.

It should be stated that both women who take the pill and those who do not can and do become pregnant. The pregnancy can be an extrauterine pregnancy EUP usually a tubal pregnancy or an intrauterine pregnancy IUP a normal pregnancy. One can measure the ratio of EUP to IUP in either group. What should happen to this ratio if one compares women who are not taking the pill to those who are.

The Ob/Gyns would argue that this ratio should remain constant, and if the reporting of ectopic pregnancy were practically unreported, as the Ob/Gyns write, one might even expect the ratio to decrease, since the numerator would become smaller. On the contrary, if the pill caused more early abortions fewer IUPs, one would expect the number of IUPs to decrease in comparison to the number of EUPs, and thus the ratio should increase. What does the literature say.

The studies to date show that women who take the pill have an increased ratio of EUP to IUP. They note that women who take the pill are far more likely to experience more EUPs per IUP than women who do not take the pill, which supports the argument that the pill is an abortifacient. The reported odds ratios of the increased risk of EUP/IUP in women taking the pill compared to women who were not taking the pill were as follows:

WHO48 found an odds ratio of 1.7 1.1-2.5 ;

Mol et al49 found an odds ratio of 1.8 0.9-3.4 ;

Job-Spira et al50 found an odds ratio of 4.3 1.5-12.6 ;

Thorburn et al51 found an odds ratio of 4.5 2.1-9.6 ; and

Coste et al52 found an odds ratio of 13.9 1.8-108.3

These clinical studies once again provide evidence that suggests that the pill acts as an abortifacient.

They write: Many factors play a part in how a family plans and spaces their children. It is not the purpose of this paper to promote nor to oppose hormonal contraception.

As a physician, I know that it is common to use a medicine or a type of procedure because previous physicians have done so. It is simply impossible for each physician to re-invent the wheel when trying to decide if a particular drug or procedure is the optimal one. Unfortunately, once one becomes accustomed to particular ways of doing things, one tends to continue to do them in a particular fashion because they have always been done that say, and new thoughts on a standard procedure are not always appreciated.

How do these statements pertain to the current argument. It has been stated that almost every physician who signed or helped write the booklet Hormonal Contraceptives: Are They Abortifacients. Is or was an obstetrician/gynecologist. It is common knowledge that virtually all Ob/Gyns prescribe the pill to their patients for contraception, in addition to other indications. Therefore, I assume and would certainly issue a retraction were I proven wrong that nearly every Ob/Gyn who signed or helped write the paper currently prescribes or has prescribed birth control pills for contraception.

The problem here is that self-proclaimed pro-life Ob/Gyns would have difficulty being unbiased in any argument about whether the pill causes early abortions, since these physicians most likely has written thousands of oral contraceptive prescriptions in their careers. If they were to admit that the pill is an abortifacient, they would be admitting that they had likely aborted hundreds of tiny children. Surely, it would be difficult for a pro-life obstetrician to fairly evaluate the abortifacient action of the pill given these circumstances.

Recently Decook et al53 have argued that if a breakthrough cycle does occur while a woman is taking the pill, her endometrial lining would become similar to that of the non-BCP user for that particular cycle. Is this an accurate statement.

To the best of this author s knowledge, that statement has no support in the medical literature. If the above statement were true, it would mean that each time a woman had a breakthrough cycle while taking the BCP if she does not become pregnant, she should experience as heavy a menstrual period as if she were not taking the pill. This phenomenon has not been described in the medical literature either.

Conclusion:

The arguments presented by the 22 physicians in the booklet Hormonal Contraceptives: Are They Abortifacient. Lack substance and actually serve to bolster the evidence that the birth control pill causes early abortions.

Footnotes

1. Faust JM. Image change for condoms. ABC News Report. Internet E-mail. 6/8/97.

2. DeCook JL, McIlhaney J, et al. Hormonal Contraceptives: Are they Abortifacients. Sparta, MI: Frontlines Publ., 1998.

3. Smith, Janet. Contraception: Why Not. Dayton, OH: One More Soul. Tele.:513-279-5433.

4. Elstein M, et al. Studies on low dose oral contraceptives: cervical and plasma hormone changes in relations to circulating d-norgestrel and 17 alpha-ethinyl estradiol concentrations. Fertility and Sterility. 27; 1;976: 892-899.

5. Wolf DP, et al. Human cervical mucus v. oral contraceptives and mucus rheologic properties. Fertility and Sterility. 32; 196-169.

6. Chang MC, Hunt DM. Effects of various progestins and estrogen on the gamete transport and fertilization in the rabbit. Fertility and Sterility, 1970: 3-686.

7. Physicians Desk Reference: 1997 The noted information can be found when looking up any oral contraceptive. Failure rate for typical use is noted to be 3 percent.

8. Potter LA. How effective are contraceptives. The determination and measurement of pregnancy rates. Obstet Gynecol. 1996; S-23S.

9. Snell, Richard. Clinical and Functional Histology for the Medical Student. Boston: Little, Brown Co., 1984, 586-591.

10. Ibid.

11. Brown HK, et al. Uterine Junctional Zone: Correlation between Histologic Findings and MR Imaging. Radiology. 1991; 179-413.

12. Fleischer AC, et al. Sonography of the endometrium during conception and nonception cycles of in vitro fertilization and embryo transfer. Fertility and Sterility. 1986; 2-447.

13. Rabinowitz R, et al. The value of ultrasonographic endometrial measurement in the prediction of pregnancy following in vitro fertilization. Fertility and Sterility. 1986; 4-826.

14. Ueno J, et al. Ultrasonographic appearance of the endometrium in natural and stimulated in vitro fertilization cycles and its correlation with outcome. Human Reproduction. 1991; 1-904.

15. Glissant A, et al. Ultrasound study of the endometrium during in vitro fertilization cycles. Fertility and Sterility. 1985; 6-789.

16. Abdalla HI, et al. Endometrial thickness: a predictor of implantation in ovum recipients. Human Reproduction. 1994; 3-365.

17. Dickey RP, et al. Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate along and with human menopausal gonadotropin. Fertility and Sterility. 1993; 6-760.

18. Gonen Y, et al. Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in in vitro fertilization. Fertility and Sterility. 1989; 6-450.

19. Schwartz LB, et al. The embryo versus endometrium controversy revisited as it relates to predicting pregnancy outcome in in vitro fertilization embryo transfer cycles. Human Reproduction. 1997; -50.

20. Shoham Z, et al. It is possible to run a successful ovulation induction program based solely on ultrasound monitoring: The importance of endometrial measurements. Fertility and Sterility. 1991; 6-841.

21. Hilliard George D, Norris HJ, Pathological Effects of Oral Contraceptives, Recent Results in Cancer Research. 1979; -71.

22. Ober WB. The effects of oral and intrauterine administration of contraceptives on the uterus. Human Pathology. 1977; 8513-527.

23. Ober WB. Synthetic progestagen-oestrogen preparations and endometrial morphology. J. Clin. Path. 1966; 8.

24. Roland M, et al. Sequential endometrial alterations during one cycle of treatment with synthetic progestagen-estrogen eompounds. Fertility and Sterility. 1966; 9.

25. Kupesic S. The first three weeks assessed by tranvaginal color doppler. J. Perinat. Med. 1996; 1-317.

26. Ibid.

27. Somkuti SG, et al. The effect of oral contraceptive pills on markers of endometrial receptivity. Fertility and Sterility. 1996; 4-488.

28. Ibid.

29. Witt B, Wolf G, et al. Relaxin, CA-125, progesterone, estradiol, Schwnagerschaft protein, and human Chorionic Gonadotropin as predictors of outcome in threatened and nonthreatened pregnancies. Fertility and Sterility. 1996; 4-488.

30. Norman RJ, et al. Inhibin and relaxin concentration in early singleton, multiple, and failing pregnancy: relationship to gonadotropin and steroid profiles. Fertility and Sterility. 1993; 59: 130-137.

31. Holmes, et al. Oral contraceptives: An assessment of their mode of action. The Lancet. June 2, 1962; 1174-1178.

32. Ritchie WGM. Ultrasound in the evaluation of normal and induced ovulation. Fertility and Sterility. 1985; 43: 167-181.

33. Petta CA, et al. Timing of onset of contraceptive effectiveness in Depo-Provera users. II. Effects on ovarian function. Fertility and Sterility. 70: 817-820.

34. Van der Vange N. Ovarian activity during low dose oral contraceptives. Contemporary Obstetrics and Gynecology. G. Chamberlain. London, Butterworths, 1988, 315-326.

35. Grimes DA, et al. Ovulation and follicular development associated with three low-dose contraceptives: A randomized controlled trial. Obstetrics Gynecology. 1994; 83: 29-34.

36. Croxatto HB, Diaz S, et al. Plasma gorgesterone levels during long-term treatment with levonorgestrel silastic implants. Acta Endocrinologica. 1982; 101: 307-311.

37. Ibid.

38. Alderson Reporting Company. Transcripts of oral arguments before court on abortion case. New York Times. April 27, 1989; B12.

39. Skegg DCG, Noonan EA, et al. Depot medroxyprogesterone acetate and breast cancer A pooled analysis of the World Health Organization and New Zealand studies. 1995; JAMA: 799-804.

40. Chang MC, Hunt DM. Effects of variious progestins and estrogen on the gamete transport and fertilization in the rabbit. Fertility and Sterility. 1970; 21: 683-686.

41. Castro-Vasquez, Macome JC, et al. On the mechanism of action of oral contraceptives. Effect of Lynestrenol on ovum implantation and ovidutal morphology in the rat. Fertility and Sterility. 1971; 22: 741-744.

42. Eden JA, et al. The effect of Clomiphene citrate on follicular phase increase in endometrial thickness and uterine volumne. Obstet. Gyn. 1989; 73: 187-190.

43. Yagel S, et al. The effect of ethinyl estradiol on endometrial thickness and uterine volume during ovulation induction by Clomiphene citrate. Fertility and Sterility. 1992; 57: 33-36.

44. Fleischer AC, et al. Sonographic depiction of endometrial changes occurring with ovulation induction. J. of Ultrasound Med. 1984; 3: 341-346.

45. Imodedemhe DA, et al. Ultrasound measurement of endometrial thickness on different ovarian simulation regimens during in vitro fertilization. Human Reproduction. 1987; 2: 545-547.

46. Dickey RP, et al. Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin. Fertility and Sterility. 1993; 59: 756-760.

47. Cunningham, et al. Williams Obstetrics, 20th Edition Standford, CT: Appleton and Lange, 1997, 580-581.

48. The WHO Task Force on intrauterine devices for fertility regulation. A multinational case-control study of ectopic pregnancy. Clin. Reprod. Fertil.1985; 3: 131-143.

49. Mol BWJ, Ankum WM, Bossuyt PMM, and Van der Veen F. Contraception and the risk of ectopic pregnancy: a meta-analysis. Contraception. 1995; 52: 337-341.

50. Job-Spira N, Fernandez H, Coste J, Papiernik E, Spira A. Risk of Chlamydia PID and oral contraceptives. JAMA. 1990; 264: 2072-2074.

51. Thornburn J, Berntsson C, Philipson M, Lindbolm B. Background factors of ectopic pregnancy. I. Frequency distribution in a case-control study. Eur. J. Obstet. Gynecol. Reprod. Biol. 1985; 23: 321-331.

52. Coste J, Job-Spira N, Fernandez H, Papiernik E, Spira A. Risk factors for ectopic pregnancy: a case-control study in France, with special focus on infectious factors. A. J. Epidemiol. 1991; 133: 839-849.

53. DeCook J, et al. Hormonal Contraceptives, Controversies and Clarification. Feb. 1999. Pro-Life Obstetrician. P.O. Box 81, Fennville, MI 49408.

54. Dr. Chris Kahlenborn specializes in internal medicine and practices in Altoona, Pennsylvania. Dr. Kahlenborn has studied the epidemiology of breast cancer in relation to abortion and oral contraceptives for the past six years and has lectured in Canada, Russia, the Philippines, and China, in addition to testifying before the Food and Drug Administration.

Breast Cancer: Its Link to Abortion and the Birth Control Pill

a book by By Chris Kahlenborn, M.D.

this is a review of that book.

Intensively researched, full of clear explanations and convincing detail, Breast Cancer: Its Link to Abortion and the Birth Control Pill cuts to the heart of the current breast cancer epidemic and gives clear, workable strategies for reducing women s cancer risk.

Breast cancer has become epidemic in the United States in recent years, with the published expectation that one of eight women in this country will incur this disease during her lifetime. Each year more than 175,000 U.S. women develop breast cancer and more than 43,000 die from it.

This is a vast change from the status 50 years ago when breast cancer was quite rare and mostly affected women who had never been pregnant or given birth. Lifestyle changes apparently account for much of this change, particularly the adoption of contraception and abortion as principal tools for fertility management.

It is a very common experience for a woman today to use contraceptive pills for several years, have an unplanned pregnancy, and abort that pregnancy. Effects on breast tissue from these events can be disastrous.

Contraceptive hormones and normal pregnancy cause breast tissue cells to multiply, resulting in new immature undifferentiated breast cells. A complete pregnancy would cause these cells to mature completely, but abortion and contraceptive hormones leave them immature and prone to cancer.

Significant increases of breast cancer risk due to abortion and to use of contraceptive hormones have been clearly defined in research studies as early as 1981. The impact of these findings has been obscured, however, by controversy among the researchers, tendentious reporting in the media, and resistance from government agencies and medical organizations. The material presented here gives a clear opportunity to promote a culture of health for women, using natural means to manage fertility, and to develop a healthier environment for them and their families.

Many research studies have examined the connection between abortion and breast cancer. One study in 1957 found that women who had abortions had double the risk of breast cancer compared to women who had not aborted.

A study in 1981 found that women who had an abortion before having a full-term pregnancy had a 140 increased risk of breast cancer, while another major study in 1994 found a 40 increased risk for the same category of women. For women in this category who were less than 18 years old and had a pregnancy of over 8 weeks, the increase found was 800.

In 1996 a meta-analysis was done on this topic, a statistical combination of all previous studies into one set of results. The combined conclusion was that women who experience an induced abortion before having a full-term pregnancy incur at least a 50 increased risk of breast cancer. These findings have not been well publicized, however, because great attention has been given to certain faulty studies with less alarming conclusions.

Concerns about contraceptive hormones causing breast cancer were raised beginning in 1972 when a series of animal research studies showed this connection. A major study on humans in 1981 showed a 125 increased risk of breast cancer for women who used hormonal contraceptives for 4 or more years before having a full-term pregnancy. Other studies since then have confirmed an increased risk for this category of at least 40. These risks are likely understated because most of the large studies had clear design flaws that would tend to depress the calculation of risk percent.

A meta-analysis done in 1990 found that, overall, the studies up to that time confirmed an increased risk of breast cancer of 72 for women under age 45 who took oral contraceptive pills for 4 or more years before having a full-term pregnancy. Use of these contraceptives for longer periods appears to carry an even higher risk. Again these findings were not well publicized because of excessive attention given to certain faulty studies whose design errors tended to understate the risk.

The risks identified in these studies increase the likelihood that a woman will suffer breast cancer. This means that women who have a higher than ordinary breast cancer risk due to well known risk factors such as nulliparity childlessness, faulty protective genes such as BRCA1 and BRCA2, or being a black American, have even higher risk when affected by abortion or hormonal contraceptives.

Calculations based on the available studies indicate that in the United States more than 46,800 women will develop breast cancer yearly due to contraceptive hormone exposure and more than 10,000 will die.

Besides the effect of hormonal contraceptives in increasing the risk of breast cancer, these chemicals have also been found to significantly increase the risk of cervical cancer, liver cancer, some types of endometrial cancer and for transmission of AIDS. These hormones reduce the risk of ovarian cancer and the most common type of endometrial cancer, but these protective effects are greatly outweighed by the added risks just mentioned.

A number of highly effective strategies for controlling breast cancer risk and some other risks as well are identified in the book. Use of Natural Family Planning instead of hormonal contraceptives would evidently reduce risk factors significantly, as would avoidance of abortion, childbirth early in a woman s life, extended breastfeeding, multiple childbirth, moderation of alcohol use, and weight loss in obese women. Some protective benefit may also be obtained by use of Vitamin A.

To adopt these strategies would involve a significant change in our current culture, but would result in many lives saved and avert a huge amount of suffering.

The author of this book, Chris Kahlenborn, is an internal medicine specialist practicing in Altoona, PA. The book is the fruit of more than 6 years spent collecting and analyzing the available research on this topic. What sparked this search was a presentation in 1993 in which the speaker described an increase in breast cancer risk due to abortion, apparently caused by hormonal changes in the woman s body.

This led Dr. Kahlenborn to wonder whether contraceptive hormones might have the same effect. He then began an exhaustive review of the research covering breast cancer s connection to both contraceptives and abortion.

Employing a highly user-friendly question and answer format, the author gives a detailed, yet understandable presentation of the major research findings to date. Technical information is interpreted in clear non-technical language, making the subject matter very accessible for the layperson and medical professional alike. There is also a clear, well-documented, presentation of the factors which have unfortunately operated to suppress this crucial information. A number of effective preventative strategies are identified and explained.

The author strongly challenges physicians, medical organizations, the research establishment, and government agencies to live up to their responsibilities for protecting women s health in this area. A final challenge is given to women themselves to take action to protect their health in the absence of effective action from responsible organizations.

Jun 20, 2013  U.S. Selected Practice Recommendations for Contraceptive Use, 2013: Adapted from the World Health Organization Selected Practice Recommendations.

Aug 16, 2015  A patient s choice of contraceptive method involves factors such as efficacy, safety, noncontraceptive benefits, cost, and personal considerations.

Oral Contraceptives. Contraindications and Adverse Effects taken from Current Medical Diagnosis and Treatment: a major medical text Oral contraceptives have been.

Crack Activex Control

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Cracking Signed ActiveX Controls

Ever come across an ActiveX control you can t afford to buy but wish to use for your own little pet project. Especially those readily available for download, but annoys the hell out of you when you try to use it as it keeps painting Evaluation Version all over itself.

Well, from time to time, I develop pet projects to keep myself entertained. Being a perfectionist, I just can t stand to see the Eval Version message appearing on my applications. Yes, the sole purpose of these apps are just so I could marvel at myself when I finish them, but how would I be able to do that if I leave the Eval Version message lying around. I want that newly polished, super shiny feeling you get when you finish something you can be proud of.

So I set out with a mission - to crack the ActiveX control that is sprinkling all those Eval Version on itself.

Surprisingly, cracking the several ActiveX controls I ve used isn t all that hard - so long as you know a little x86 ASM and have the right tools such as the W32Dasm for Windows . Most ActiveX controls are smart enough to prevent simple cracks such as looking up the Eval Version message and skipping them via a jmp, but in order to draw the text on the screen, the message would still have to be decrypted somehow and placed in the memory. And, THAT is usually the weakest link. What I usually do is, I d change the opcodes directly in the memory while I step through the ASM in an IDE I use CodeGear RAD Studio 2007 so I could see the effects immediately. If things go wrong, I d simply break out of the debug session and restart.

Once you have cracked it, use a hex editor to change the bytes you ve changed in the IDE - you ll have to note down a few instructions before and after the ones you re about to change when you were debugging in the IDE, as there may be more than one occurrence of the bytes you search for. For example, there could be numerous occurrences of 33C9 hex, which translates to xor ecx,ecx.

For normal exe / dll files, patching the file and then doing a final test would ve been the end of it. With a signed ActiveX file, however, you d find that if you try to use the ActiveX in your IDE, it ll complain that the ActiveX cannot be loaded. That simply means that the hash usually SHA1 in the ActiveX no longer matches the file - and rightly so. This is easily circumvented though - all you need to do is re-sign the file, and then re-import that into your IDE.

Lucky for us, there s no need to un-sign the ActiveX file before re-signing it with our own cert. Here s a link with step-by-step guide for signing an ActiveX file -

In the next installment, I d probably blog about cracking signed. NET assemblies, if responses are good for this one.

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